Researchers Identify Brain Region That May Influence Hypertension and Suggest Treatment Approach

Sat, 11 Apr 2026 14:50:00 +0200

A recent study conducted by researchers from the University of São Paulo and the University of Auckland has identified a potential new cause of high blood pressure related to a specific brain region called the lateral parafacial (pFL) area. This region, primarily associated with breathing control, appears to also influence blood vessel constriction, which may contribute to hypertension. In experiments with rats, activating pFL neurons increased blood pressure by stimulating other brain circuits, while inactivating them returned pressure to normal levels. The findings could explain why roughly 40 percent of patients still struggle with uncontrolled hypertension despite medication. The study also links these mechanisms to sleep apnea, a condition that elevates blood pressure due to disrupted oxygen and CO2 levels during sleep. Looking forward, the researchers aim to target the carotid bodies—sensors in the neck that affect pFL activity—as a potential treatment strategy, possibly using a